In fact they are trendy enough that I was able to create a Pinterest board of examples of people using them in their home decor. What is interesting is they aren't all necessarily in a typical "rustic" type of setting - instead people seem to be using them to add a bit of an organic feel to more modern style decor. I kind of dig it myself, they don't have much of an ick factor for me, and I like the way they look in a lot of the rooms I found online. Here is just a couple of examples from my board:
From The Shabby Nest
And here are the antlers I found, they are all at auction right now!